Webmd provides information about interactions between vinblastine intravenous and selectedantineoplasticsstrongcyp3a4inhibitors. Highlights of prescribing information perforation can occur. This leaflet summarizes the most important information about diflucan. If you encounter technical difficulties in viewing our product information please contact. Severe local tissue necrosis will occur if there is extravasation during administration. Therefore, reserve azole antifungals, including voriconazole, for patients. Vinblastine sulfate vinblastine sulfate injection can cause fetal harm when administered to a pregnant woman. It is freely soluble in water, soluble in methanol, and slightly soluble in ethanol. Previously, the generic name was vincaleukoblastine, abbreviated vlb. Vincristine fda prescribing information, side effects and uses.
Adult patients with newly diagnosed stage 3 or 4 classical hodgkin lymphoma chl in combination with chemotherapy adriamycin, vinblastine, and dacarbazine consolidation therapy in chl. Information available at present suggests that vinblastine sulfate may be useful, either alone or in combination with other oncolytic drugs, for the treatment of. There are many options to help minimize or prevent the side effects of vinblastine. Prescribing amikacin sulfate injection in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drugresistant bacteria. This leaflet does not take the place of talking with your doctor about your condition or your treatment. Tepadina thiotepa for injection, for intravenous, intracavitary, or intravesical use. Vincristine and vinblastine exhibit differential activity against. Vincristine sulfate vincristine sulfate this product information is intended only for residents of the united states.
Please contact pfizer canada medical information at 1 800 4636001 with any comments or inquiries. See full prescribing information for instructions on reconstitution of vfend lyophilized powder for intravenous use and reconstitution of vfend oral. Prescribing information pdf open prescribing information. Previously untreated stage iiiiv chl adult patients with previously untreated stage iiiiv classical hodgkin lymphoma chl in combination with doxorubicin, vinblastine, and dacarbazine. Adult patients with chl at high risk of coming back or becoming worse after a stem cell. Although no abnormalities of the human fetus have been associated with the use of vinblastine, information on its use during. Rituxan hycela rituximab and hyaluronidase human injection, for subcutaneous use initial u. Jul 01, 2018 prescribing amikacin sulfate injection in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drugresistant bacteria. Prescribing information pr vinblastine sulphate injection teva standard 1 mgml 10 mg 10 ml sterile solution antineoplastic agent control number. Adriamycin must not be given by the intramuscular or subcutaneous route.
Vinblastine vbl, sold under the brand name velban among others, is a chemotherapy. Although information on the use of vinblastine during pregnancy is limited, the drug may cause foetal toxicity when administered to pregnant women. Similar to other vinca alkaloids, vinblastine binds to the microtubular proteins of. Wellbutrin bupropion hydrochloride tablets, for oral use. For instructions on the usehandling of the product see section 6. The drug causes resorption of foetuses in animals and produces gross foetal abnormalities in surviving offspring.
Please refer to mims product monographs for specific and locally approved prescribing information. In intact tectal plates from mouse embryos, vinorelbine, vincristine and vinblastine inhibited mitotic microtubule formation at the same concentration 2 m, inducing a blockade of cells at metaphase. Vinblastines side effects are usually quite manageable. Highlights of prescribing information these highlights do not include all the information needed to use rituxan hycela safely and effectively. Please see additional important safety information on pages 45 and full prescribing information, including boxed warning, attached or at. Like the related vincristine, it inhibits cell division by interfering with the mitotic spindle.
These highlights do not include all the information needed to use wellbutrin safely and effectively. Vinblastine vbl, sold under the brand name velban among others, is a chemotherapy medication, typically used with other medications, to treat a number of types of cancer. The authors make no claims of the accuracy of the information contained herein. The national hiv curriculum is an aids education and training center aetc program supported by the health resources and services administration hrsa of the u. The incidences for the adverse effects are based on product monographs. Always consult your healthcare provider if you have questions or concerns.
Side effects of vinblastine sulfate vinblastine sulfate. To obtain uptodate information about the treatment of overdose, a good. Please discuss all dose reductions delays with the relevant consultant before prescribing, if appropriate. Death has occurred with intrathecal administration. The use of the information on this website does not create a physician.
Vinblastine, sold under the brand name velban among others, is a chemotherapy medication, typically used with other medications, to treat a number of types of cancer. Varubi prescribing information, tersera therapeutics llc 2. Vinblastine is the salt of a naturallyoccurring vinca alkaloid obtained from the. According to the american cancer society, bladder cancer is responsible for about 5% of all new cancers in the united states. Caprelsa vandetanib tablets for oral use initial u. The information on this website is intended for informational purposes only and is not a substitute for medical advice. Marqibo vincristine sulfate liposome injection has different dosage recommendations than. Highlights of prescribing information these highlights do not include a ll the information needed to use tepadina safely and effectively. Vinblastine sulfate vinblastine sulfate injection dailymed. Animal studies suggest that vinblastine may be teratogenic. There are more than 15 case reports concerning the use of vinblastine during the first trimester, mostly in. Find patient medical information for vinblastine intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Dec 01, 2019 vinblastine official prescribing information for healthcare professionals.
Emendaprepitant capsules, for oral use emend aprepitant for oral suspension. Left ventricular dysfunction and embryofetal toxicity. Highlights of prescribing information these highlights do. Jc virus infection resulting in pml and death can occur in adcetristreated patients. This information is independently developed by mims based on vinblastine from various references and is provided for your reference only. Vinblastine sulfate vinblastine sulfate dose, indications. Afinitor everolimus tablets, for oral use afinitor disperz everolimus tablets for oral suspension.
Highlights of prescribing information these highlights do not include all the information needed to use perjeta safely and effectively. Vinblastine is an alkaloid derived from the periwinkle plant. Chemotherapy hepatotoxicity and dose modification in. Patient information detrol detrol tolterodine tartrate tablets read the patient information that comes with detrol before you start using it and each time you get a refill. Important safety information boxed warning progressive multifocal leukoencephalopathy pml. If you would like more information, talk with your doctor.
With the exception of epilation, leukopenia, and neurologic side effects, adverse reactions generally have not persisted for longer than. It is important for you to tell your doctor how you are feeling during your treatment with vinblastine injection. Vinblastine dose will be rounded to the nearest 1mg up if halfway there is no maximum dose of vinblastine in this protocol. Highlights of prescribing information these highlights do not include all the information needed to use velcade safely and effectively. Fortunately, the rates of new bladder cancer cases have decreased. Mar 01, 2020 vincristine sulfate injection, usp is a sterile, preservativefree, singledose only solution available for intravenous use in 2 ml 1 mg and 2 mg vials. Adcetris is a prescription medicine used for the treatment of. Highlights of prescribing information ideation, suicide. Each ml contains 1 mg vincristine sulfate, usp, 100 mg mannitol and water for injection, usp.
Although no abnormalities of the human fetus have been associated with the use of vinblastine, information on its use during pregnancy is limited. See full prescribing information for rituxan hycela. This patient information sheet applies only to approved uses of the drug. You can ask your pharmacist or doctor for information about diflucan that is written for health professionals. Velban vinblastine dosing, indications, interactions. Animal studies with vinblastine sulfate suggest that teratogenic effects may occur. Together with tesaro official site for healthcare professionals. The recommended dose in combination with chemotherapy doxorubicin a, vinblastine v and dacarbazine d avd is 1. General aspects of drug metabolism and patterns of hepatic injury are discussed separately, as is reactivation of hepatitis b hbv viral infection in patients treated with immunosuppressive therapy, and hepatotoxicity associated with checkpoint inhibitor immunotherapy. Syringes containing this product must be labelled, using the auxiliary. Safety and efficacy of rolapitant for prevention of chemotherapyinduced nausea and vomiting after administration of cisplatinbased highly emetogenic chemotherapy in patients with cancer. Gobbi pg, broglia c, merli f, dellolio m, stelitano c, iannitto e, et al.
Sulfuric acid or sodium hydroxide have been added for ph control. Vincristine fda prescribing information, side effects. Keep a list of them with you to show your doctor or pharmacist each time you get a new medicine. Pdr drug summaries are concise pointofcare prescribing, dosing and administering information to help phsyicans more efficiently and accurately prescribe in their practice pdr s drug summaries are available free of charge and serve as a great resource for us based mds, dos, nps and pas in patient practice. Any use of the information is subject, at all times, to ccos terms and conditions. Differential activity of vincristine and vinblastine. Find clinical trials for vinblastine sulfate check for trials from ncis list of cancer clinical trials now accepting patients. Vinorelbine injection usp should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents.
Administration information extravasation bleomycin neutral dacarbazine vesicant. Vinblastine fda prescribing information, side effects. Vinblastine sulphate 1 mgml injection summary of product. Prior to the use of the drug, patients should be advised of the possibility of untoward symptoms. However, much of the information may also apply to unapproved uses that are being studied. Primary prophylaxis with growth factor support gcsf is recommended for allpatientswith. Please see important safety information on slides 2427 and accompanying full prescribing information. Product monograph download pdf, 582kb canadian regulations limit the scope of information we are permitted to give on prescription drugs via the internet or other means. This preparation should be administered by individuals experienced in the administration of vinblastine sulfate.
See full prescribing information for emend capsules and emend for oral suspension. Vinblastine fda prescribing information, side effects and uses. Adcetris brentuximab vedotin dosing and administration guide. See full prescribing information for complete boxed warning. Canadian regulations limit the scope of information we are permitted to give on prescription drugs via the internet or other means. Detrol tolterodine tartrate fdaapproved patient labeling. Highlights of prescribing information emend capsules and. Vinblastines side effects should improve after treatment is complete. Chemotherapy protocol lymphoma bleomycindacarbazine.
Therefore, the use of vinblastine during pregnancy is contraindicated unless the expected benefits clearly outweigh the risk of side effects. See full prescribing information for afinitorafinitor disperz. There are no adequate and controlled studies to date using vinblastine in pregnant. Vinblastine sulfate can cause fetal harm when administered to a pregnant woman. You can also visit the diflucan internet site at lab038010. Information on the use of vinblastine sulfate during human pregnancy is very limited. Product information adriamycin solution for injection warnings 1.
The approach may be different depending on the clinical circumstances. Syringes containing this product should be labeled, using the auxiliary sticker. The following side effects are common occurring in greater than 30% for patients taking vinblastine. Intrathecal administration of other vinca alkaloids has resulted in death. Highlights of prescribing information these highlights do not. It is the salt of an alkaloid extracted from vinca rosea linn. Your doctor may need to delay your treatment or change your dose if you experience certain side effects. Serious irreversible myocardial toxicity with delayed congestive. Vincristine sulfate injection, usp is a sterile, preservativefree, singledose only solution available for intravenous use in 2 ml 1 mg and 2 mg vials. Highlights of prescribing information these highlights do not include all the information needed to use afinitorafinitor disperz safely and effectively. This includes hodgkins lymphoma, nonsmall cell lung cancer, bladder cancer, brain cancer, melanoma, and testicular cancer. Perjeta pertuzumab injection, for intravenous use initial u. Vinblastine sulfate is the salt of an alkaloid extracted from vinca rosea linn. Vials of vinblastine sulfate for injection usp contain 10 mg.
Vinblastine velbe treatment national hiv curriculum. Therapeutic uses, prescribing information and product availability may vary between countries. Highlights of prescribing information these highlights do not include all the information needed to use emendcapsules and emend for oral suspension safely and effectively. Warning for intravenous use only fatal if given by other routes see warnings and precautions 5. Vinblastine sulfate for injection usp is vincaleukoblastine, sulfate 1. Interactions between vinblastine intravenous and selected. In general, the incidence of adverse reactions attending the use of vinblastine sulfate appears to be related to the size of the dose employed.
Ask your pharmacist or doctor for a copy of the manufacturers information for the patient. Please consult a qualified health professional for more detailed information. The clinical formulation is supplied in a sterile form for intravenous use only. It is extremely important that the intravenous needle or catheter be properly positioned before any vinblastine sulfate is injected. Adcetris brentuximab vedotin is indicated for the treatment of.